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Postpartum Depression — Deal Benchmarks & Valuation

Median Upfront
$333M
Range: $173M - $491M
Total Deal Value
$1.8B
Range: $1.1B - $2.5B
Royalty Rate
7.9% - 15.9%
Tiered up to 19.9%
Dev Milestones
$328M
Range: $211M - $446M

Market Analysis

Postpartum Depression is one of the most actively transacted indications in women's health licensing. Phase 2 deals for postpartum depression carry a median total deal value of $1.8B, with upfront payments ranging from $173M to $491M. The recommended deal structure allocates approximately 18% to upfront payments and 82% to milestones.

Milestone structures for postpartum depression deals allocate $328M to development milestones, $343M to regulatory milestones, and $820M to commercial milestones. Royalty rates range from 7.9% to 15.9% at the base tier, with tiered escalation reaching 11.9%-19.9% on peak sales.

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Frequently Asked Questions

What are typical deal terms for postpartum depression licensing?
Phase 2 postpartum depression licensing deals average $333M in upfront payments with $1.8B total deal value. The 18/82 upfront/milestone split reflects the risk profile at this clinical stage.
What royalty rates are standard for postpartum depression deals?
Base royalty rates for postpartum depression transactions range from 7.9% to 15.9%, with tiered escalations reaching 11.9%-19.9% on peak sales. Rates are influenced by mechanism differentiation, competitive positioning, and territorial scope.
How are postpartum depression deal milestones structured?
Postpartum Depression deals allocate approximately 82% of total deal value to milestones. Development milestones ($328M) make up the largest share, followed by commercial milestones ($820M) and regulatory milestones ($343M).
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