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Endometriosis — Deal Benchmarks & Valuation

Median Upfront
$326M
Range: $169M - $481M
Total Deal Value
$1.8B
Range: $1.1B - $2.5B
Royalty Rate
7.9% - 15.8%
Tiered up to 19.8%
Dev Milestones
$321M
Range: $206M - $436M

Market Analysis

Endometriosis is one of the most actively transacted indications in women's health licensing. Phase 2 deals for endometriosis carry a median total deal value of $1.8B, with upfront payments ranging from $169M to $481M. The recommended deal structure allocates approximately 18% to upfront payments and 82% to milestones.

Milestone structures for endometriosis deals allocate $321M to development milestones, $336M to regulatory milestones, and $803M to commercial milestones. Royalty rates range from 7.9% to 15.8% at the base tier, with tiered escalation reaching 11.9%-19.8% on peak sales.

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Frequently Asked Questions

What are typical deal terms for endometriosis licensing?
Phase 2 endometriosis licensing deals average $326M in upfront payments with $1.8B total deal value. The 18/82 upfront/milestone split reflects the risk profile at this clinical stage.
What royalty rates are standard for endometriosis deals?
Base royalty rates for endometriosis transactions range from 7.9% to 15.8%, with tiered escalations reaching 11.9%-19.8% on peak sales. Rates are influenced by mechanism differentiation, competitive positioning, and territorial scope.
How are endometriosis deal milestones structured?
Endometriosis deals allocate approximately 82% of total deal value to milestones. Development milestones ($321M) make up the largest share, followed by commercial milestones ($803M) and regulatory milestones ($336M).
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