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C. difficile Infection — Deal Benchmarks & Valuation

Median Upfront
$636M
Range: $370M - $881M
Total Deal Value
$2.4B
Range: $1.7B - $3.2B
Royalty Rate
8.3% - 16.5%
Tiered up to 20.5%
Dev Milestones
$395M
Range: $282M - $513M

Market Analysis

C. difficile Infection is one of the most actively transacted indications in infectious disease licensing. Phase 2 deals for c. difficile infection carry a median total deal value of $2.4B, with upfront payments ranging from $370M to $881M. The recommended deal structure allocates approximately 26% to upfront payments and 74% to milestones.

Milestone structures for c. difficile infection deals allocate $395M to development milestones, $413M to regulatory milestones, and $988M to commercial milestones. Royalty rates range from 8.3% to 16.5% at the base tier, with tiered escalation reaching 12.3%-20.5% on peak sales.

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Frequently Asked Questions

What are typical deal terms for c. difficile infection licensing?
Phase 2 c. difficile infection licensing deals average $636M in upfront payments with $2.4B total deal value. The 26/74 upfront/milestone split reflects the risk profile at this clinical stage.
What royalty rates are standard for c. difficile infection deals?
Base royalty rates for c. difficile infection transactions range from 8.3% to 16.5%, with tiered escalations reaching 12.3%-20.5% on peak sales. Rates are influenced by mechanism differentiation, competitive positioning, and territorial scope.
How are c. difficile infection deal milestones structured?
C. difficile Infection deals allocate approximately 74% of total deal value to milestones. Development milestones ($395M) make up the largest share, followed by commercial milestones ($988M) and regulatory milestones ($413M).
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