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Cardiomyopathy — Deal Benchmarks & Valuation

Median Upfront
$928M
Range: $505M - $1.3B
Total Deal Value
$4.7B
Range: $3.0B - $6.3B
Royalty Rate
10.6% - 21.3%
Tiered up to 25.3%
Dev Milestones
$823M
Range: $556M - $1.1B

Market Analysis

Cardiomyopathy is one of the most actively transacted indications in cardiovascular licensing. Phase 2 deals for cardiomyopathy carry a median total deal value of $4.7B, with upfront payments ranging from $505M to $1.3B. The recommended deal structure allocates approximately 20% to upfront payments and 80% to milestones.

Milestone structures for cardiomyopathy deals allocate $823M to development milestones, $1.0B to regulatory milestones, and $1.9B to commercial milestones. Royalty rates range from 10.6% to 21.3% at the base tier, with tiered escalation reaching 14.6%-25.3% on peak sales.

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Frequently Asked Questions

What are typical deal terms for cardiomyopathy licensing?
Phase 2 cardiomyopathy licensing deals average $928M in upfront payments with $4.7B total deal value. The 20/80 upfront/milestone split reflects the risk profile at this clinical stage.
What royalty rates are standard for cardiomyopathy deals?
Base royalty rates for cardiomyopathy transactions range from 10.6% to 21.3%, with tiered escalations reaching 14.6%-25.3% on peak sales. Rates are influenced by mechanism differentiation, competitive positioning, and territorial scope.
How are cardiomyopathy deal milestones structured?
Cardiomyopathy deals allocate approximately 80% of total deal value to milestones. Development milestones ($823M) make up the largest share, followed by commercial milestones ($1.9B) and regulatory milestones ($1.0B).
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