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Pulmonary Arterial Hypertension — Deal Benchmarks & Valuation

Median Upfront
$664M
Range: $361M - $958M
Total Deal Value
$3.3B
Range: $2.2B - $4.5B
Royalty Rate
9.6% - 19.3%
Tiered up to 23.3%
Dev Milestones
$589M
Range: $398M - $781M

Market Analysis

Pulmonary Arterial Hypertension is one of the most actively transacted indications in cardiovascular licensing. Phase 2 deals for pulmonary arterial hypertension carry a median total deal value of $3.3B, with upfront payments ranging from $361M to $958M. The recommended deal structure allocates approximately 20% to upfront payments and 80% to milestones.

Milestone structures for pulmonary arterial hypertension deals allocate $589M to development milestones, $749M to regulatory milestones, and $1.3B to commercial milestones. Royalty rates range from 9.6% to 19.3% at the base tier, with tiered escalation reaching 13.6%-23.3% on peak sales.

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Frequently Asked Questions

What are typical deal terms for pulmonary arterial hypertension licensing?
Phase 2 pulmonary arterial hypertension licensing deals average $664M in upfront payments with $3.3B total deal value. The 20/80 upfront/milestone split reflects the risk profile at this clinical stage.
What royalty rates are standard for pulmonary arterial hypertension deals?
Base royalty rates for pulmonary arterial hypertension transactions range from 9.6% to 19.3%, with tiered escalations reaching 13.6%-23.3% on peak sales. Rates are influenced by mechanism differentiation, competitive positioning, and territorial scope.
How are pulmonary arterial hypertension deal milestones structured?
Pulmonary Arterial Hypertension deals allocate approximately 80% of total deal value to milestones. Development milestones ($589M) make up the largest share, followed by commercial milestones ($1.3B) and regulatory milestones ($749M).
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