Rett Syndrome — Deal Benchmarks & Valuation
Market Analysis
Rett Syndrome is one of the most actively transacted indications in neurology licensing. Phase 1 deals for rett syndrome carry a median total deal value of $1.7B, with upfront payments ranging from $48M to $197M. The recommended deal structure allocates approximately 7% to upfront payments and 93% to milestones.
Milestone structures for rett syndrome deals allocate $815M to development milestones, $489M to regulatory milestones, and $326M to commercial milestones. Royalty rates range from 7.6% to 15.2% at the base tier, with tiered escalation reaching 11.6%-19.2% on peak sales.
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Frequently Asked Questions
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