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ALS (Amyotrophic Lateral Sclerosis) — Deal Benchmarks & Valuation

Median Upfront
$433M
Range: $214M - $659M
Total Deal Value
$3.9B
Range: $2.3B - $5.5B
Royalty Rate
13.3% - 21.3%
Tiered up to 25.3%
Dev Milestones
$1.1B
Range: $701M - $1.6B

Market Analysis

ALS (Amyotrophic Lateral Sclerosis) is one of the most actively transacted indications in neurology licensing. Phase 2 deals for als (amyotrophic lateral sclerosis) carry a median total deal value of $3.9B, with upfront payments ranging from $214M to $659M. The recommended deal structure allocates approximately 11% to upfront payments and 89% to milestones.

Milestone structures for als (amyotrophic lateral sclerosis) deals allocate $1.1B to development milestones, $1.2B to regulatory milestones, and $1.1B to commercial milestones. Royalty rates range from 13.3% to 21.3% at the base tier, with tiered escalation reaching 17.3%-25.3% on peak sales.

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Frequently Asked Questions

What are typical deal terms for als (amyotrophic lateral sclerosis) licensing?
Phase 2 als (amyotrophic lateral sclerosis) licensing deals average $433M in upfront payments with $3.9B total deal value. The 11/89 upfront/milestone split reflects the risk profile at this clinical stage.
What royalty rates are standard for als (amyotrophic lateral sclerosis) deals?
Base royalty rates for als (amyotrophic lateral sclerosis) transactions range from 13.3% to 21.3%, with tiered escalations reaching 17.3%-25.3% on peak sales. Rates are influenced by mechanism differentiation, competitive positioning, and territorial scope.
How are als (amyotrophic lateral sclerosis) deal milestones structured?
ALS (Amyotrophic Lateral Sclerosis) deals allocate approximately 89% of total deal value to milestones. Development milestones ($1.1B) make up the largest share, followed by commercial milestones ($1.1B) and regulatory milestones ($1.2B).
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