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Huntington's Disease — Deal Benchmarks & Valuation

Median Upfront
$140M
Range: $56M - $232M
Total Deal Value
$2.1B
Range: $1.0B - $3.1B
Royalty Rate
8% - 15.9%
Tiered up to 19.9%
Dev Milestones
$960M
Range: $487M - $1.4B

Market Analysis

Huntington's Disease is one of the most actively transacted indications in neurology licensing. Phase 1 deals for huntington's disease carry a median total deal value of $2.1B, with upfront payments ranging from $56M to $232M. The recommended deal structure allocates approximately 7% to upfront payments and 93% to milestones.

Milestone structures for huntington's disease deals allocate $960M to development milestones, $576M to regulatory milestones, and $384M to commercial milestones. Royalty rates range from 8% to 15.9% at the base tier, with tiered escalation reaching 12%-19.9% on peak sales.

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Frequently Asked Questions

What are typical deal terms for huntington's disease licensing?
Phase 1 huntington's disease licensing deals average $140M in upfront payments with $2.1B total deal value. The 7/93 upfront/milestone split reflects the risk profile at this clinical stage.
What royalty rates are standard for huntington's disease deals?
Base royalty rates for huntington's disease transactions range from 8% to 15.9%, with tiered escalations reaching 12%-19.9% on peak sales. Rates are influenced by mechanism differentiation, competitive positioning, and territorial scope.
How are huntington's disease deal milestones structured?
Huntington's Disease deals allocate approximately 93% of total deal value to milestones. Development milestones ($960M) make up the largest share, followed by commercial milestones ($384M) and regulatory milestones ($576M).
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