Hemophilia A — Deal Benchmarks & Valuation
Market Analysis
Hemophilia A is one of the most actively transacted indications in rare disease licensing. Phase 2 deals for hemophilia a carry a median total deal value of $1.9B, with upfront payments ranging from $162M to $510M. The recommended deal structure allocates approximately 18% to upfront payments and 82% to milestones.
Milestone structures for hemophilia a deals allocate $333M to development milestones, $379M to regulatory milestones, and $803M to commercial milestones. Royalty rates range from 8.2% to 16.4% at the base tier, with tiered escalation reaching 12.2%-20.4% on peak sales.
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Frequently Asked Questions
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