Cystic Fibrosis — Deal Benchmarks & Valuation
Market Analysis
Cystic Fibrosis is one of the most actively transacted indications in rare disease licensing. Phase 2 deals for cystic fibrosis carry a median total deal value of $2.3B, with upfront payments ranging from $205M to $633M. The recommended deal structure allocates approximately 19% to upfront payments and 81% to milestones.
Milestone structures for cystic fibrosis deals allocate $405M to development milestones, $461M to regulatory milestones, and $976M to commercial milestones. Royalty rates range from 7.7% to 15.4% at the base tier, with tiered escalation reaching 11.7%-19.4% on peak sales.
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