Familial Hypercholesterolemia — Deal Benchmarks & Valuation
Market Analysis
Familial Hypercholesterolemia is one of the most actively transacted indications in metabolic licensing. Phase 2 deals for familial hypercholesterolemia carry a median total deal value of $2.9B, with upfront payments ranging from $334M to $873M. The recommended deal structure allocates approximately 21% to upfront payments and 79% to milestones.
Milestone structures for familial hypercholesterolemia deals allocate $410M to development milestones, $501M to regulatory milestones, and $1.4B to commercial milestones. Royalty rates range from 14.1% to 25.8% at the base tier, with tiered escalation reaching 18.1%-29.8% on peak sales.
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Frequently Asked Questions
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