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NASH / MASH — Deal Benchmarks & Valuation

Median Upfront
$701M
Range: $385M - $1.0B
Total Deal Value
$3.3B
Range: $2.2B - $4.5B
Royalty Rate
14.7% - 26.9%
Tiered up to 30.9%
Dev Milestones
$472M
Range: $320M - $627M

Market Analysis

NASH / MASH is one of the most actively transacted indications in metabolic licensing. Phase 2 deals for nash / mash carry a median total deal value of $3.3B, with upfront payments ranging from $385M to $1.0B. The recommended deal structure allocates approximately 21% to upfront payments and 79% to milestones.

Milestone structures for nash / mash deals allocate $472M to development milestones, $577M to regulatory milestones, and $1.6B to commercial milestones. Royalty rates range from 14.7% to 26.9% at the base tier, with tiered escalation reaching 18.7%-30.9% on peak sales.

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Frequently Asked Questions

What are typical deal terms for nash / mash licensing?
Phase 2 nash / mash licensing deals average $701M in upfront payments with $3.3B total deal value. The 21/79 upfront/milestone split reflects the risk profile at this clinical stage.
What royalty rates are standard for nash / mash deals?
Base royalty rates for nash / mash transactions range from 14.7% to 26.9%, with tiered escalations reaching 18.7%-30.9% on peak sales. Rates are influenced by mechanism differentiation, competitive positioning, and territorial scope.
How are nash / mash deal milestones structured?
NASH / MASH deals allocate approximately 79% of total deal value to milestones. Development milestones ($472M) make up the largest share, followed by commercial milestones ($1.6B) and regulatory milestones ($577M).
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