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Dravet Syndrome — Deal Benchmarks & Valuation

Median Upfront
$367M
Range: $181M - $558M
Total Deal Value
$3.3B
Range: $2.0B - $4.6B
Royalty Rate
12.7% - 20.3%
Tiered up to 24.3%
Dev Milestones
$968M
Range: $594M - $1.3B

Market Analysis

Dravet Syndrome is one of the most actively transacted indications in neurology licensing. Phase 2 deals for dravet syndrome carry a median total deal value of $3.3B, with upfront payments ranging from $181M to $558M. The recommended deal structure allocates approximately 11% to upfront payments and 89% to milestones.

Milestone structures for dravet syndrome deals allocate $968M to development milestones, $1.1B to regulatory milestones, and $910M to commercial milestones. Royalty rates range from 12.7% to 20.3% at the base tier, with tiered escalation reaching 16.7%-24.3% on peak sales.

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Frequently Asked Questions

What are typical deal terms for dravet syndrome licensing?
Phase 2 dravet syndrome licensing deals average $367M in upfront payments with $3.3B total deal value. The 11/89 upfront/milestone split reflects the risk profile at this clinical stage.
What royalty rates are standard for dravet syndrome deals?
Base royalty rates for dravet syndrome transactions range from 12.7% to 20.3%, with tiered escalations reaching 16.7%-24.3% on peak sales. Rates are influenced by mechanism differentiation, competitive positioning, and territorial scope.
How are dravet syndrome deal milestones structured?
Dravet Syndrome deals allocate approximately 89% of total deal value to milestones. Development milestones ($968M) make up the largest share, followed by commercial milestones ($910M) and regulatory milestones ($1.1B).
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