RNAi / siRNA Phase 1 Licensing Benchmarks
Deal economics across 7 transactions with 7 disclosed upfront payments. Primary-source-verified from SEC EDGAR, FTC filings, and direct research.
Median Upfront
$120M
7 deals with terms
Median Total Value
$1.5B
Upfront + milestones
Royalty Range
8%--17%
Average low--high
Deal Count
7
2019--2025
The median upfront payment for phase 1 rnai / sirna licensing deals is $120M, based on 7 deals with disclosed terms from 2019--2025. Total deal values (including milestones) reach a median of $1.5B. Royalty rates typically range from 8% to 17%. All data is primary-source-verified from SEC EDGAR, FTC pre-merger filings, and company press releases.
Representative Transactions
| Licensor | Licensee | Year | Upfront | Total Value |
|---|---|---|---|---|
| Dicerna Pharmaceuticals | Novo Nordisk | 2021 | $3.3B | $3.3B |
| Ionis Pharmaceuticals | Roche | 2023 | $200M | $1.6B |
| Argo Biopharmaceutical | Novartis | 2025 | $160M | $5.2B |
Showing 3 of 7 deals with disclosed terms. Full comp set available in the report.
Full RNAi/siRNA phase-1 Comp Set
Get the complete analysis -- 7 deals with upfronts, milestones, royalties, and term structures.
Primary-source-verified from SEC EDGAR, FTC filings, and direct research
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This analysis draws from the Ambrosia Ventures proprietary deal database (1,600+ verified biopharma transactions, 2019--2025). All deal terms are primary-source-verified from SEC EDGAR (10-K, 10-Q, 8-K filings), FTC pre-merger notifications, FDA Orange Book, and company press releases. No secondary-source or scraped data is included. Medians are calculated from deals with disclosed financial terms only.