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Celiac Disease — Deal Benchmarks & Valuation

Median Upfront
$536M
Range: $287M - $776M
Total Deal Value
$2.7B
Range: $1.7B - $3.7B
Royalty Rate
7.7% - 14.3%
Tiered up to 18.3%
Dev Milestones
$461M
Range: $301M - $623M

Market Analysis

Celiac Disease is one of the most actively transacted indications in gastroenterology licensing. Phase 2 deals for celiac disease carry a median total deal value of $2.7B, with upfront payments ranging from $287M to $776M. The recommended deal structure allocates approximately 20% to upfront payments and 80% to milestones.

Milestone structures for celiac disease deals allocate $461M to development milestones, $549M to regulatory milestones, and $1.2B to commercial milestones. Royalty rates range from 7.7% to 14.3% at the base tier, with tiered escalation reaching 11.7%-18.3% on peak sales.

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Frequently Asked Questions

What are typical deal terms for celiac disease licensing?
Phase 2 celiac disease licensing deals average $536M in upfront payments with $2.7B total deal value. The 20/80 upfront/milestone split reflects the risk profile at this clinical stage.
What royalty rates are standard for celiac disease deals?
Base royalty rates for celiac disease transactions range from 7.7% to 14.3%, with tiered escalations reaching 11.7%-18.3% on peak sales. Rates are influenced by mechanism differentiation, competitive positioning, and territorial scope.
How are celiac disease deal milestones structured?
Celiac Disease deals allocate approximately 80% of total deal value to milestones. Development milestones ($461M) make up the largest share, followed by commercial milestones ($1.2B) and regulatory milestones ($549M).
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