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Bipolar Disorder — Deal Benchmarks & Valuation

Median Upfront
$295M
Range: $147M - $447M
Total Deal Value
$2.6B
Range: $1.6B - $3.7B
Royalty Rate
11.8% - 18.9%
Tiered up to 22.9%
Dev Milestones
$766M
Range: $469M - $1.1B

Market Analysis

Bipolar Disorder is one of the most actively transacted indications in neurology licensing. Phase 2 deals for bipolar disorder carry a median total deal value of $2.6B, with upfront payments ranging from $147M to $447M. The recommended deal structure allocates approximately 11% to upfront payments and 89% to milestones.

Milestone structures for bipolar disorder deals allocate $766M to development milestones, $835M to regulatory milestones, and $719M to commercial milestones. Royalty rates range from 11.8% to 18.9% at the base tier, with tiered escalation reaching 15.8%-22.9% on peak sales.

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Frequently Asked Questions

What are typical deal terms for bipolar disorder licensing?
Phase 2 bipolar disorder licensing deals average $295M in upfront payments with $2.6B total deal value. The 11/89 upfront/milestone split reflects the risk profile at this clinical stage.
What royalty rates are standard for bipolar disorder deals?
Base royalty rates for bipolar disorder transactions range from 11.8% to 18.9%, with tiered escalations reaching 15.8%-22.9% on peak sales. Rates are influenced by mechanism differentiation, competitive positioning, and territorial scope.
How are bipolar disorder deal milestones structured?
Bipolar Disorder deals allocate approximately 89% of total deal value to milestones. Development milestones ($766M) make up the largest share, followed by commercial milestones ($719M) and regulatory milestones ($835M).
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