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Aplastic Anemia — Deal Benchmarks & Valuation

Median Upfront
$622M
Range: $326M - $911M
Total Deal Value
$3.1B
Range: $1.9B - $4.2B
Royalty Rate
8.6% - 16.2%
Tiered up to 20.2%
Dev Milestones
$515M
Range: $332M - $699M

Market Analysis

Aplastic Anemia is one of the most actively transacted indications in hematology licensing. Phase 2 deals for aplastic anemia carry a median total deal value of $3.1B, with upfront payments ranging from $326M to $911M. The recommended deal structure allocates approximately 20% to upfront payments and 80% to milestones.

Milestone structures for aplastic anemia deals allocate $515M to development milestones, $613M to regulatory milestones, and $1.3B to commercial milestones. Royalty rates range from 8.6% to 16.2% at the base tier, with tiered escalation reaching 12.6%-20.2% on peak sales.

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Frequently Asked Questions

What are typical deal terms for aplastic anemia licensing?
Phase 2 aplastic anemia licensing deals average $622M in upfront payments with $3.1B total deal value. The 20/80 upfront/milestone split reflects the risk profile at this clinical stage.
What royalty rates are standard for aplastic anemia deals?
Base royalty rates for aplastic anemia transactions range from 8.6% to 16.2%, with tiered escalations reaching 12.6%-20.2% on peak sales. Rates are influenced by mechanism differentiation, competitive positioning, and territorial scope.
How are aplastic anemia deal milestones structured?
Aplastic Anemia deals allocate approximately 80% of total deal value to milestones. Development milestones ($515M) make up the largest share, followed by commercial milestones ($1.3B) and regulatory milestones ($613M).
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