Angelman Syndrome — Deal Benchmarks & Valuation
Market Analysis
Angelman Syndrome is one of the most actively transacted indications in neurology licensing. Phase 1 deals for angelman syndrome carry a median total deal value of $1.8B, with upfront payments ranging from $50M to $207M. The recommended deal structure allocates approximately 7% to upfront payments and 93% to milestones.
Milestone structures for angelman syndrome deals allocate $857M to development milestones, $514M to regulatory milestones, and $343M to commercial milestones. Royalty rates range from 7.7% to 15.4% at the base tier, with tiered escalation reaching 11.7%-19.4% on peak sales.
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