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Addiction / Substance Use Disorders — Deal Benchmarks & Valuation

Median Upfront
$283M
Range: $141M - $428M
Total Deal Value
$2.5B
Range: $1.5B - $3.5B
Royalty Rate
11.7% - 18.7%
Tiered up to 22.7%
Dev Milestones
$734M
Range: $450M - $1.0B

Market Analysis

Addiction / Substance Use Disorders is one of the most actively transacted indications in neurology licensing. Phase 2 deals for addiction / substance use disorders carry a median total deal value of $2.5B, with upfront payments ranging from $141M to $428M. The recommended deal structure allocates approximately 11% to upfront payments and 89% to milestones.

Milestone structures for addiction / substance use disorders deals allocate $734M to development milestones, $801M to regulatory milestones, and $689M to commercial milestones. Royalty rates range from 11.7% to 18.7% at the base tier, with tiered escalation reaching 15.7%-22.7% on peak sales.

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Frequently Asked Questions

What are typical deal terms for addiction / substance use disorders licensing?
Phase 2 addiction / substance use disorders licensing deals average $283M in upfront payments with $2.5B total deal value. The 11/89 upfront/milestone split reflects the risk profile at this clinical stage.
What royalty rates are standard for addiction / substance use disorders deals?
Base royalty rates for addiction / substance use disorders transactions range from 11.7% to 18.7%, with tiered escalations reaching 15.7%-22.7% on peak sales. Rates are influenced by mechanism differentiation, competitive positioning, and territorial scope.
How are addiction / substance use disorders deal milestones structured?
Addiction / Substance Use Disorders deals allocate approximately 89% of total deal value to milestones. Development milestones ($734M) make up the largest share, followed by commercial milestones ($689M) and regulatory milestones ($801M).
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