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Uveal Melanoma — Deal Benchmarks & Valuation

Median Upfront
$266M
Range: $148M - $376M
Total Deal Value
$1.7B
Range: $1.1B - $2.3B
Royalty Rate
11.9% - 19.5%
Tiered up to 23.5%
Dev Milestones
$355M
Range: $237M - $475M

Market Analysis

Uveal Melanoma is one of the most actively transacted indications in oncology licensing. Phase 2 deals for uveal melanoma carry a median total deal value of $1.7B, with upfront payments ranging from $148M to $376M. The recommended deal structure allocates approximately 16% to upfront payments and 84% to milestones.

Milestone structures for uveal melanoma deals allocate $355M to development milestones, $568M to regulatory milestones, and $497M to commercial milestones. Royalty rates range from 11.9% to 19.5% at the base tier, with tiered escalation reaching 15.9%-23.5% on peak sales.

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Frequently Asked Questions

What are typical deal terms for uveal melanoma licensing?
Phase 2 uveal melanoma licensing deals average $266M in upfront payments with $1.7B total deal value. The 16/84 upfront/milestone split reflects the risk profile at this clinical stage.
What royalty rates are standard for uveal melanoma deals?
Base royalty rates for uveal melanoma transactions range from 11.9% to 19.5%, with tiered escalations reaching 15.9%-23.5% on peak sales. Rates are influenced by mechanism differentiation, competitive positioning, and territorial scope.
How are uveal melanoma deal milestones structured?
Uveal Melanoma deals allocate approximately 84% of total deal value to milestones. Development milestones ($355M) make up the largest share, followed by commercial milestones ($497M) and regulatory milestones ($568M).
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