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Ulcerative Colitis — Deal Benchmarks & Valuation

Median Upfront
$853M
Range: $453M - $1.2B
Total Deal Value
$4.4B
Range: $2.8B - $6.1B
Royalty Rate
15.7% - 26.2%
Tiered up to 30.2%
Dev Milestones
$719M
Range: $461M - $980M

Market Analysis

Ulcerative Colitis is one of the most actively transacted indications in immunology licensing. Phase 2 deals for ulcerative colitis carry a median total deal value of $4.4B, with upfront payments ranging from $453M to $1.2B. The recommended deal structure allocates approximately 19% to upfront payments and 81% to milestones.

Milestone structures for ulcerative colitis deals allocate $719M to development milestones, $1.3B to regulatory milestones, and $1.6B to commercial milestones. Royalty rates range from 15.7% to 26.2% at the base tier, with tiered escalation reaching 19.7%-30.2% on peak sales.

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Frequently Asked Questions

What are typical deal terms for ulcerative colitis licensing?
Phase 2 ulcerative colitis licensing deals average $853M in upfront payments with $4.4B total deal value. The 19/81 upfront/milestone split reflects the risk profile at this clinical stage.
What royalty rates are standard for ulcerative colitis deals?
Base royalty rates for ulcerative colitis transactions range from 15.7% to 26.2%, with tiered escalations reaching 19.7%-30.2% on peak sales. Rates are influenced by mechanism differentiation, competitive positioning, and territorial scope.
How are ulcerative colitis deal milestones structured?
Ulcerative Colitis deals allocate approximately 81% of total deal value to milestones. Development milestones ($719M) make up the largest share, followed by commercial milestones ($1.6B) and regulatory milestones ($1.3B).
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