Preclinical vs Phase 1 — Rare Disease Deal Valuation Comparison
Market Analysis
The Preclinical to Phase 1 transition in rare disease represents a significant value inflection point. Phase 1 deals carry a median total deal value of $846M compared to $499M at Preclinical, a 70% premium reflecting clinical de-risking. Upfront payments increase from $36M to $91M.
Deal structures shift as assets advance. Preclinical deals allocate 7% to upfront and 93% to milestones, while Phase 1 deals shift to 11%/89%. Development milestones move from $199M to $264M, and royalty rates evolve from 4.5%-8.9% to 5.6%-11.2%.
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Frequently Asked Questions
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