RNAi / siRNA vs ASO — Oncology Deal Terms Comparison
Market Analysis
In oncology, RNAi / siRNA and ASO represent two of the most actively transacted modalities. At Phase 2, RNAi / siRNA deals carry a median total deal value of $1.9B with $297M upfront, compared to $1.9B total value and $297M upfront for ASO. The valuation difference reflects distinct risk-reward profiles, manufacturing complexity, and competitive dynamics.
Milestone structures diverge between the two modalities. RNAi / siRNA development milestones average $397M versus $397M for ASO. Commercial milestones are $555M for RNAi / siRNA and $555M for ASO. Royalty rates range from 12.3%-20.1% for RNAi / siRNA and 12.3%-20.1% for ASO.
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Frequently Asked Questions
How do RNAi / siRNA and ASO deal terms compare in oncology?
Which modality commands higher royalty rates: RNAi / siRNA or ASO?
How do milestone structures differ between RNAi / siRNA and ASO?
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