ASO vs RNAi / siRNA — Neurology Deal Terms Comparison
Market Analysis
In neurology, ASO and RNAi / siRNA represent two of the most actively transacted modalities. At Phase 2, ASO deals carry a median total deal value of $3.5B with $389M upfront, compared to $3.5B total value and $395M upfront for RNAi / siRNA. The valuation difference reflects distinct risk-reward profiles, manufacturing complexity, and competitive dynamics.
Milestone structures diverge between the two modalities. ASO development milestones average $1.0B versus $1.0B for RNAi / siRNA. Commercial milestones are $963M for ASO and $961M for RNAi / siRNA. Royalty rates range from 12.9%-20.6% for ASO and 12.9%-20.6% for RNAi / siRNA.
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Frequently Asked Questions
How do ASO and RNAi / siRNA deal terms compare in neurology?
Which modality commands higher royalty rates: ASO or RNAi / siRNA?
How do milestone structures differ between ASO and RNAi / siRNA?
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