ASO vs Gene Therapy — Neurology Deal Terms Comparison
Market Analysis
In neurology, ASO and Gene Therapy represent two of the most actively transacted modalities. At Phase 2, ASO deals carry a median total deal value of $3.5B with $389M upfront, compared to $3.0B total value and $331M upfront for Gene Therapy. The valuation difference reflects distinct risk-reward profiles, manufacturing complexity, and competitive dynamics.
Milestone structures diverge between the two modalities. ASO development milestones average $1.0B versus $874M for Gene Therapy. Commercial milestones are $963M for ASO and $821M for Gene Therapy. Royalty rates range from 12.9%-20.6% for ASO and 12.3%-19.7% for Gene Therapy.
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Frequently Asked Questions
How do ASO and Gene Therapy deal terms compare in neurology?
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