Phase 1 Immunology & Autoimmune Deal Benchmarks
Market Analysis
Phase 1 immunology & autoimmune licensing deals carry a median total deal value of $1.3B, with upfront payments ranging from $64M to $215M. At this stage, deal structures are heavily milestone-weighted, reflecting the significant clinical risk ahead. The recommended split allocates 11% to upfront and 89% to milestones.
The immunology & autoimmune landscape at the phase 1 stage is characterized by high competitive intensity, particularly in inflammatory bowel disease and autoimmune conditions. Development milestones average $400M, regulatory milestones contribute $400M, and commercial milestones reach $343M. CAR-T for autoimmune diseases, TL1A inhibitors, and next-generation targeted therapies are reshaping the licensing landscape.
Royalty rates for phase 1 immunology & autoimmune deals range from 8.8% to 15.3% at the base tier, with high-tier escalation to 19.3%. Earlier-stage royalties are at the lower end of industry ranges, reflecting higher clinical risk.
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Frequently Asked Questions
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