Skip to main content

Oral Integrin vs TL1A Inhibitor — Immunology Deal Terms Comparison

Oral Integrin Median Upfront
$629M
Total: $3.3B
TL1A Inhibitor Median Upfront
$676M
Total: $3.5B
Oral Integrin Royalties
14.4%-23.9%
Tiered to 27.9%
TL1A Inhibitor Royalties
14.7%-24.5%
Tiered to 28.5%

Market Analysis

In immunology, Oral Integrin and TL1A Inhibitor represent two of the most actively transacted modalities. At Phase 2, Oral Integrin deals carry a median total deal value of $3.3B with $629M upfront, compared to $3.5B total value and $676M upfront for TL1A Inhibitor. The valuation difference reflects distinct risk-reward profiles, manufacturing complexity, and competitive dynamics.

Milestone structures diverge between the two modalities. Oral Integrin development milestones average $531M versus $570M for TL1A Inhibitor. Commercial milestones are $1.2B for Oral Integrin and $1.3B for TL1A Inhibitor. Royalty rates range from 14.4%-23.9% for Oral Integrin and 14.7%-24.5% for TL1A Inhibitor.

Customize these benchmarks for your asset

Adjust phase, modality, competitive position, and 10+ other parameters.

Open Calculator

Frequently Asked Questions

How do Oral Integrin and TL1A Inhibitor deal terms compare in immunology?
Oral Integrin Phase 2 deals average $3.3B total deal value ($629M upfront), while TL1A Inhibitor deals average $3.5B ($676M upfront). The difference reflects modality-specific risk profiles, manufacturing considerations, and competitive positioning.
Which modality commands higher royalty rates: Oral Integrin or TL1A Inhibitor?
Oral Integrin base royalties range from 14.4% to 23.9%, while TL1A Inhibitor royalties range from 14.7% to 24.5%. High-tier escalation reaches 27.9% for Oral Integrin and 28.5% for TL1A Inhibitor.
How do milestone structures differ between Oral Integrin and TL1A Inhibitor?
Oral Integrin deals allocate $531M to development milestones vs $570M for TL1A Inhibitor. Commercial milestones are $1.2B (Oral Integrin) vs $1.3B (TL1A Inhibitor), reflecting different commercialization profiles and market expectations.
PRO

Full Benchmark Analysis

Complete deal term ranges, comparable transactions, and negotiation insights.

Start 7-Day Free Trial

$299/mo after trial · Cancel anytime

Ready to Calculate Your Deal Terms?

Get instant, customized benchmarks based on real market data from 1,600+ biopharma licensing deals.

Start Calculating
For Funds & Advisors

Need the full deal landscape?

The Deal Intelligence Brief covers every modality and deal structure for this indication — 52 deal calculations, AI strategic narrative, comparable transactions, partner matching, and white-label branding. Delivered in 24 hours.

Configure Brief — $2,500All-inclusive · White-label · Walkthrough included