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Acute Myeloid Leukemia (AML) — Deal Benchmarks & Valuation

Median Upfront
$339M
Range: $189M - $479M
Total Deal Value
$2.2B
Range: $1.4B - $2.9B
Royalty Rate
12.8% - 20.9%
Tiered up to 24.9%
Dev Milestones
$453M
Range: $303M - $607M

Market Analysis

Acute Myeloid Leukemia (AML) is one of the most actively transacted indications in oncology licensing. Phase 2 deals for acute myeloid leukemia (aml) carry a median total deal value of $2.2B, with upfront payments ranging from $189M to $479M. The recommended deal structure allocates approximately 16% to upfront payments and 84% to milestones.

Milestone structures for acute myeloid leukemia (aml) deals allocate $453M to development milestones, $725M to regulatory milestones, and $635M to commercial milestones. Royalty rates range from 12.8% to 20.9% at the base tier, with tiered escalation reaching 16.8%-24.9% on peak sales.

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Frequently Asked Questions

What are typical deal terms for acute myeloid leukemia (aml) licensing?
Phase 2 acute myeloid leukemia (aml) licensing deals average $339M in upfront payments with $2.2B total deal value. The 16/84 upfront/milestone split reflects the risk profile at this clinical stage.
What royalty rates are standard for acute myeloid leukemia (aml) deals?
Base royalty rates for acute myeloid leukemia (aml) transactions range from 12.8% to 20.9%, with tiered escalations reaching 16.8%-24.9% on peak sales. Rates are influenced by mechanism differentiation, competitive positioning, and territorial scope.
How are acute myeloid leukemia (aml) deal milestones structured?
Acute Myeloid Leukemia (AML) deals allocate approximately 84% of total deal value to milestones. Development milestones ($453M) make up the largest share, followed by commercial milestones ($635M) and regulatory milestones ($725M).
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